Although surrogate outcomes are often used in this way, enabling smaller, faster, cheaper clinical trials; they do have one great disadvantage. To illustrate the perils of relying on surrogates, This report, Surrogate Outcomes in Clinical Trials-A Cautionary Tale, compiles a table of drugs, approved on the basis of surrogate outcome data, which after adoption into practice were shown to be harmful through clinical trials or meta-analyses (eTable). Registration required. (Source: JAMA Internal Medicine 3/25/13).
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