The Institute for Clinical and Economic Review (ICER) has posted two Draft Scoping Documents for public comment. One document outlines ICER’s review of the comparative clinical effectiveness and value of three calcitonin gene-related peptide (CGRP) inhibitors for prevention of migraine. The second outlines ICER’s update to a 2016 report on treatments for plaque psoriasis. The scoping documents will be open to public comment for three weeks until 5 p.m. EST Dec. 22.
ICER’s review of CGRP inhibitors for migraine will include erenumab (Amgen/Novartis), fremanezumab (Teva), and galcanezumab (Eli Lilly). Each of the three therapies is currently under FDA review, with approval decisions expected throughout mid-late 2018.
The plaque psoriasis report update will incorporate data that has emerged since ICER’s initial review. It will also include recently-approved guselkumab (Tremfya, Johnson & Johnson), as well as tildrakizumab (Sun Pharma/Merck) and certolizumab pegol (Cimzia, UCB), for which approval decisions are expected in March and May of 2018, respectively. Certolizumab pegol is currently approved for use in rheumatoid arthritis.
Both topics will be discussed at a future public meeting of one of ICER’s three independent evidence appraisal committees.