In the midst of the COVID-19 pandemic, the biopharma/biotech industry has engaged in the rapid development of diagnostic tests, treatments, and vaccines for novel coronavirus. Because this is a new pathogen with substantial morbidity and mortality, programs including treatment trials are moving forward quickly, although data on viral shedding, seroprevalence, and transmissibility are still accumulating. Clinical development and medical affairs scientists as well as operational specialists engaged in clinical research must balance the lack of information and uncertainty with the urgent need to be agile, pragmatic, and creative in the design and implementation of real-world pandemic studies. In this webinar, we will share design considerations and challenges for a real-world data (RWD) external control arm for a COVID-19 treatment. We will discuss core scientific considerations for the development of an external control arm to rapidly collect standard of care (SOC) data in treatment trials lacking randomization to an SOC comparator. Additionally, we will discuss the operational strategies to rapidly deliver RWD on SOC during a global pandemic.